Chalfont is named after Chalfont St Giles in Buckinghamshire, England. Chalfont was the home of William Penn's first wife, and William Penn is buried at Jordans Quaker Meeting House near Chalfont St Giles.
The Chalfont Historic District is listed on the National Register of Historic Places and contains many American colonial and Victorian-style houses. Several of these are former residences which are currently occupied by businesses and are concentrated near the intersection of Butler Avenue (U.S. Route 202 Business) and North Main Street (Pennsylvania Route 152) and extend along North Main Street. Delaware Valley University.